Context The attitudes of medical professionals towards physician assisted dying have been widely discussed. Less explored is the level of agreement among physicians on the possibility of ‘rational suicide’—a considered suicide act made by a sound mind and a precondition of assisted dying legislation. Objective To assess attitudes towards rational suicide in a representative sample of senior doctors in England and Wales. Methods A postal survey was conducted of 1000 consultants and general practitioners randomly selected from a commercially available database. (...) The main outcome of interest was level of agreement with a statement about rational suicide. Results The corrected participation rate was 50%; 363 questionnaires were analysed. Overall 72% of doctors agreed with the possibility of rational suicide, 17% disagreed, and 11% were neutral. Doctors who identified themselves as being more religious were more likely to disagree. Some doctors who disagreed with legalisation of physician assisted suicide nevertheless agreed with the concept of rational suicide. Conclusions Most senior doctors in England and Wales feel that rational suicide is possible. There was no association with specialty. Strong religious belief was associated with disagreement, although levels of agreement were still high in people reporting the strongest religious belief. Most doctors who were opposed to physician assisted suicide believed that rational suicide was possible, suggesting that some medical opposition is best explained by other factors such as concerns of assessment and protection of vulnerable patients. (shrink)

To the evolutionarily oriented clinical psychiatrist, the discipline of behavioural ecology is a fertile basic science. Human psychology discusses variation in terms of means, standard deviations, heritabilities, and so on, but behavioural ecology deals with mutually incompatible alternative behavioural strategies, the heritable variation being maintained by negative frequency-dependent selection. I suggest that behavioural ecology should be included in the interdisciplinary dialogue recommended by Keller & Miller (K&M). (Published Online November 9 2006).

Reciprocal altruism involves foregoing an immediate benefit for the sake of a greater long-term reward. It follows that individuals who exhibit a stronger preference for future over immediate rewards should be more disposed to engage in reciprocal altruism – in other words, ‘patient’ people should be more cooperative. The present study tested this prediction by investigating whether participants’ contributions in a public-good game correlated with their ‘discount rate’. The hypothesis was supported: patient people are indeed more cooperative. The paper discusses (...) alternative interpretations of this result, and makes some suggestions for future research. (shrink)

BackgroundThere is increasing need for peer reviewers as the scientific literature grows. Formal education in biostatistics and research methodology during residency training is lacking. In this pilot study, we addressed these issues by evaluating a novel method of teaching residents about biostatistics and research methodology using peer review of standardized manuscripts. We hypothesized that mentored peer review would improve resident knowledge and perception of these concepts more than non-mentored peer review, while improving review quality.MethodsA partially blinded, randomized, controlled multi-center study (...) was performed. Seventy-eight neurology residents from nine US neurology programs were randomized to receive mentoring from a local faculty member or not. Within a year, residents reviewed a baseline manuscript and four subsequent manuscripts, all with introduced errors designed to teach fundamental review concepts. In the mentored group, mentors discussed completed reviews with residents. Primary outcome measure was change in knowledge score between pre- and post-tests, measuring epidemiology and biostatistics knowledge. Secondary outcome measures included level of confidence in the use and interpretation of statistical concepts before and after intervention, and RQI score for baseline and final manuscripts.ResultsSixty-four residents (82%) completed initial review with gradual decline in completion on subsequent reviews. Change in primary outcome, the difference between pre- and post-test knowledge scores, did not differ between mentored (−8.5%) and non-mentored (−13.9%) residents (p = 0.48). Significant differences in secondary outcomes (using 5-point Likert scale, 5 = strongly agree) included mentored residents reporting enhanced understanding of research methodology (3.69 vs 2.61; p = 0.001), understanding of manuscripts (3.73 vs 2.87; p = 0.006), and application of study results to clinical practice (3.65 vs 2.78; p = 0.005) compared to non-mentored residents. There was no difference between groups in level of interest in peer review (3.00 vs 3.09; p = 0.72) or the quality of manuscript review assessed by the Review Quality Instrument (RQI) (3.25 vs 3.06; p = 0.50).ConclusionsWe used mentored peer review of standardized manuscripts to teach biostatistics and research methodology and introduce the peer review process to residents. Though knowledge level did not change, mentored residents had enhanced perception in their abilities to understand research methodology and manuscripts and apply study results to clinical practice. (shrink)

This is a comprehensive reference source on 18th-century authors writing in the English language about philosophical ideas and issues. It features authors taken from 1689 through to the mid-19th century, the period beginning with John Locke and ending with Dugald Stewart. The word philosophical is used in a wide, 18th-century sense. Therefore, the Dictionary includes epistemology, ethics, aesthetics, education, politics, rhetoric, science, medicine, biology, geology, chemistry and theology.

Computer programs are used to obtain and store information about the online activities of users of the web. Many people are concerned about this practice because they believe that it can violate users' rights to privacy or result in violations of them. This belief is based on the assumption that the information obtained and stored with the use of the programs includes personal information. My main aim in this paper is to argue that this assumption is false. I discuss the (...) import of this result for computer ethics. If my thesis is correct, using the programs cannot violate a person's right to privacy and cannot result in violations of a right to privacy. Nevertheless it is prima facie morally wrong because, as I explain, it encourages people to perform actions that diminish the well-being of others. I discuss the implications of my thesis for the obligations of online businesses with regard to the relevant information. (shrink)

In which a scientist searches for an empirical explanation for phenomenal experience, spurred by his instinctual belief that life is meaningful. What links conscious experience of pain, joy, color, and smell to bioelectrical activity in the brain? How can anything physical give rise to nonphysical, subjective, conscious states? Christof Koch has devoted much of his career to bridging the seemingly unbridgeable gap between the physics of the brain and phenomenal experience. This engaging book--part scientific overview, part memoir, part futurist speculation--describes (...) Koch's search for an empirical explanation for consciousness. Koch recounts not only the birth of the modern science of consciousness but also the subterranean motivation for his quest--his instinctual belief that life is meaningful. Koch describes his own groundbreaking work with Francis Crick in the 1990s and 2000s and the gradual emergence of consciousness as a legitimate topic for scientific investigation. Present at this paradigm shift were Koch and a handful of colleagues, including Ned Block, David Chalmers, Stanislas Dehaene, Giulio Tononi, Wolf Singer, and others. Aiding and abetting it were new techniques to listen in on the activity of individual nerve cells, clinical studies, and brain-imaging technologies that allowed safe and noninvasive study of the human brain in action. Koch gives us stories from the front lines of modern research into the neurobiology of consciousness as well as his own reflections on a variety of topics, including the distinction between attention and awareness, the unconscious, how neurons respond to Homer Simpson, the physics and biology of free will, dogs, Der Ring des Nibelungen, sentient machines, the loss of his belief in a personal God, and sadness. All of them are signposts in the pursuit of his life's work--to uncover the roots of consciousness. (shrink)

The adaptationist framework is necessary and sufficient for unifying the social and natural sciences. Gintis's “beliefs, preferences, and constraints” (BPC) model compares unfavorably to this framework because it lacks criteria for determining special design, incorrectly assumes that standard evolutionary theory predicts individual rationality maximisation, does not adequately recognize the impact of psychological mechanisms on culture, and is mute on the behavioural implications of intragenomic conflict. (Published Online April 27 2007).

This paper investigates some delicate tradeoffs between the generality of an algorithmic learning device and the quality of the programs it learns successfully. There are results to the effect that, thanks to small increases in generality of a learning device, the computational complexity of some successfully learned programs is provably unalterably suboptimal. There are also results in which the complexity of successfully learned programs is asymptotically optimal and the learning device is general, but, still thanks to the generality, some of (...) those optimal, learned programs are provably unalterably information deficient—in some cases, deficient as to safe, algorithmic extractability/provability of the fact that they are even approximately optimal. For these results, the safe, algorithmic methods of information extraction will be by proofs in arbitrary, true, computably axiomatizable extensions of Peano Arithmetic. (shrink)

In ‘Naming and Necessity,’ Saul Kripke defends a number of essentialist claims. One of them is that having a certain origin is a necessary property of a material thing. Used in connection with a human being or, presumably, a living thing of another kind whose members sexually reproduce, ‘necessity of origin’ means that the organism must have been born of those individuals who are its parents, i.e., whose body tissues are sources of the sperm and egg from which it issued, (...) in the actual world. To say that the origin of an inanimate material thing is necessary is to say that having its origin in the hunk of matter from which it came is essential to it. (shrink)

Integrin‐mediated cell adhesion and subsequent cell spreading are essential for the growth and survival of many cell types. While integrin engagement is known to activate various signalling pathways, the role that cell spreading plays in the control of growth and survival is not clear. Using a novel technique, however, Chen et al.(1) demonstrate that the effect of cell spreading on growth and survival is not a consequence of increased area of contact with the extracellular matrix, supporting the hypothesis that regulation (...) through changes in cell tension and architecture play a key role. (shrink)

Each of the following sentences expresses a strong intuition about physical things: (a) a physical object is a three-dimensional spatial thing; (b) some physical things can, in the strict sense, remain the same thing through minor changes in their parts; (c) if x and y are physical things with the same spatiotemporal location, then x is strictly identical with y; (d) if x is a proper part of an existing physical thing and x occupies an occupiable region of space, then (...) x is itself an existing physical thing. There is a familiar argument that purports to prove that not all of (a)--(d) can be part of our ordinary concept of a physical thing. Its strategy for defending this claim is showing that at least one of (a)--(d) must-be false. The reason it gives for concluding that (a)--(d) are inconsistent is, appropriately, that they give rise to a paradox: according to the argument, (c) commits us to identifying products of a part-loss, yet (a), (b), and (d) yield the result that the products are different things. (shrink)

Researchers and practitioners are increasingly using machine-generated synthetic data as a tool for advancing health science and practice, by expanding access to health data while—potentially—mitigating privacy and related ethical concerns around data sharing. While using synthetic data in this way holds promise, we argue that it also raises significant ethical, legal, and policy concerns, including persistent privacy and security problems, accuracy and reliability issues, worries about fairness and bias, and new regulatory challenges. The virtue of synthetic data is often understood (...) to be its detachment from the data subjects whose measurement data is used to generate it. However, we argue that addressing the ethical issues synthetic data raises might require bringing data subjects back into the picture, finding ways that researchers and data subjects can be more meaningfully engaged in the construction and evaluation of datasets and in the creation of institutional safeguards that promote responsible use. (shrink)

Researchers and practitioners are increasingly using machine‐generated synthetic data as a tool for advancing health science and practice, by expanding access to health data while—potentially—mitigating privacy and related ethical concerns around data sharing. While using synthetic data in this way holds promise, we argue that it also raises significant ethical, legal, and policy concerns, including persistent privacy and security problems, accuracy and reliability issues, worries about fairness and bias, and new regulatory challenges. The virtue of synthetic data is often understood (...) to be its detachment from the data subjects whose measurement data is used to generate it. However, we argue that addressing the ethical issues synthetic data raises might require bringing data subjects back into the picture, finding ways that researchers and data subjects can be more meaningfully engaged in the construction and evaluation of datasets and in the creation of institutional safeguards that promote responsible use. (shrink)

Reply to a commentary by Felicitas Holzer and Ignacio Mastroleoon “Models of Consent to Return of Incidental Findings in Genomic Research.”.

In his influential book 'Making Things Happen' and in other places, Jim Woodward has noted some affinities between his own account of causation and that of Menzies and Price, but argued that the latter view is implausibly ‘subjective’. In this piece I discuss Woodward’s criticisms. I argue that the Menzies and Price view is not as different from Woodward’s own account as he believes, and that in so far as it is different, it has some advantages whose importance (...) Woodward misses; but also that the Menzies and Price view lacks some elements whose importance Woodward rightly stresses. When properly characterized, however, the ‘subjectivity’ survives unscathed. (shrink)

Why is the future so different from the past? Why does the past affect the future and not the other way round? The universe began with the Big Bang - will it end with a `Big Crunch'? Now in paperback, this book presents an innovative and controversial view of time and contemporary physics. Price urges physicists, philosophers, and anyone who has ever pondered the paradoxes of time to look at the world from a fresh perspective, and throws fascinating new (...) light on some of the great mysteries of the universe. (shrink)

Does not the theory of a general tendency of entropy to diminish [sic] take too much for granted? To a certain extent it is supported by experimental evidence. We must accept such evidence as far as it goes and no further. We have no right to supplement it by a large draft of the scientific imagination.

(1992). The agonic and hedonic modes: Definition, usage, and the promotion of mental health. World Futures: Vol. 35, Socio-Mental Bimodality, pp. 87-113.

The first half of Mr. Burgener's article is a very clear and very just exposition of my views. There is, however, one point which he may not have appreciated fully, and that is the "climate of opinion" in which I was writing, and against which I was reacting. One of my main aims was to protest against the transformation of the empiricist epistemology into a linguistic epistemology, a transformation initiated by the Logical Positivists of the 1930's, and completed by Wittgenstein (...) and his disciples. Hence the amount of space devoted to sign-cognition, to the intelligence of animals, and to image-thinking, all of which are non-verbal or pre-verbal. But, as he has surmised, I am really just an old-fashioned British empiricist. I am fighting on two fronts, as it were, throughout the book: against a purely linguistic conception of thinking on one side, and against the "classical" inspective conception of it on the other. And in this two-fold battle, I am taking just the line which Locke, Berkeley, and Hume would have taken if they had been alive today: one which they do in fact suggest in their writings, though of course they could not anticipate the lengths to which the purely linguistic or verbalistic conception of thinking would go, or how it would ally itself with a behavioristic conception of human personality. One of the things I most object to in current British philosophy is the attack which is made on all sides of the "inner life," the attempt to show that there is no such thing, or that it is a mere muddle to suppose there is, or that to the extent that it does exist it is of no importance. Perhaps there is some connection between this attack on the inner life and the attack on private life which is made by the politicians, social reformers, and economic planners. Perhaps they are only two aspects of the same thing. Anyway, between them they have gone a long way towards a kind of "dehumanisation" of man; and this seems to me one of the darkest features of the very dark age in which we live. I feel concerned about it not only as an epistemologist, but also as a religious person, or at least as a person who is interested in religion in a very undenominational way. Religion, as I view it, is very closely connected with the "inner life"; and if one is forbidden to take an interest in the "inner life," religion will wither away from sheer inanition. At any rate, the most mystical types of religion will, and these are the ones which seem to me the most important. (shrink)

How are we to understand Aristotle's famous doctrine of the mean? "If ten pounds are too much for a particular person to eat and two too little, it does not follow that the trainer will order six pounds"... In fact, the relation of morality to physical health is more intimate than mere analogy. Emotions involve a bodily process (cp On the Soul 403al6ff): for example, 'Anger is productive of heat' (On the Parts ofAnimals 650b35), while 'Fear is, indeed, a kind (...) of chill' (Rhetoric 1389b32). The hot temper of youth and the cool temper of old age, to take two extremes, are corollaries of physical extremes, of literal heat and cold respectively (Rhetoric 1389a2ff). In general, moral as well as bodily excellences are supervenient upon physical states; specific to moral excellence is what it supervenes upon, viz bodily pleasures and plains (Physics 246b3-247a20, an early passage not relevantly superseded). Health and virtue are both grounded upon the physiological condition of a psycho-physical entity... Yet it is hard to view the physiology of virtue as more than a general precondition. It more satisfactorily identifies natural virtue than virtue proper. The blood of young men is heated by nature (as though by wine), so that they are hot-tempered and hopeful; this makes them less timorous and more confident, and so more courageous, than the old (Rhetoric 1389al8ff). But the properly brave man is one 'who faces and who fears the right things and from the right motive, in the right way and at the right time' (11 5b1b7ff). (shrink)

It is well-known that Plato’s Republic introduces a tripartition of the incarnate human soul; yet quite how to interpret his ‘parts’ 1 is debated. On a strong reading, they are psychological subjects – much as we take ourselves to be, but homunculi, not homines. On a weak reading, they are something less paradoxical: aspects of ourselves, identified by characteristic mental states, dispositional and occurrent, that tend to come into conflict. Christopher Bobonich supports the strong reading in his Plato’s Utopia Recast: (...) His Later Ethics and Politics. In his The Brute Within: Appetitive Desire in Plato and Aristotle, Hendrik Lorenz agrees with Bobonich that the parts of the soul are ‘the subjects or bearers of psychological states’. Any ascription to my Mental Conflict of the opposed, weak view needs qualification: my Plato is highly ambivalent.2 But my intention here is less to defend an earlier self – though I predict failing to escape it – than to reconsider tripartition in the Republic in the light of Bobonich’s virtuosity and Lorenz’s lucidity. They persuade me of the inexhaustibility of the text, notably within Book 4 from 436 to 439. About these pages we may indeed disagree: they find them decisive in favour of their view, as I don’t. When Socrates remarks, ‘Let us have our understanding still more precise, lest as we proceed we become involved in dispute’, he was not anticipating the dissensions of interpreters. (shrink)